A-Mectin 6 mg Tablet: Each tablet contains Ivermectin BP 6 mg.
A-Mectin 12 mg Tablet: Each tablet contains Ivermectin BP 12 mg.
Ivermectin is a member of the avermectin class of broad-spectrum antiparasitic agents. It binds selectively and with high affinity to glutamate-gated chloride ion channels which occur in nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. It may also impair normal intrauterine development of parasites and may inhibit their release from the uteri of gravid female parasites.
Ivermectin is indicated for the treatment of the following infections:
Strongyloidiasis of the intestinal tract.: Ivermectin is indicated for the treatment of intestinal strongyloidiasis due to the nematode parasite *Strongyloides stercoralis*.
Onchocerciasis.: Ivermectin is indicated for the treatment of onchocerciasis due to the nematode parasite *Onchocerca volvulus*.
Strongyloidiasis:
Body Weight (kg).
Dose:
15-24.
3 mg.
25-35.
6 mg.
36-50.
9 mg.
51-65.
12 mg.
66-79.
15 mg.
>80.
200 mcg/kg.
Onchocerciasis:
Body Weight (kg).
Dose:
15-25.
3 mg.
26-44.
6 mg.
45-64.
9 mg.
65-84.
12 mg.
>80.
150 mcg/kg.
Or as directed by the physician.
As with other microfilaricidal drugs, there was an increase in the microfilariae count in the anterior chamber of the eye at day 3 after treatment in some patients.
Pregnancy Category C: It is excreted in human milk in low concentrations. Treatment of mothers who intend to breast feed should only be undertaken when the risk of delayed treatment to the mother outweighs the possible risk to the newborn.
Safety and effectiveness in pediatric patients weighing less than 15 kg have not been established.
Microfilaricidal drugs, such as diethylcarbamazine citrate, might cause cutaneous and/or systemic reactions of varying severity and ophthalmological reactions in patients with onchocerciasis. Stop taking Ivermectin and seek emergency medical attention if you experience symptoms of arare but serious allergic reaction including swelling of the lips, tongue or face.