VeterinaryAntidiarrheals

Metronidazole

Composition

Each gm contains Metronidazole BP 300 mg.

Description

Metronidazole is a member of the imidazole class of antibacterial drugs and is classified therapeutically as an antiprotozoal agent. The 5-nitro group of metronidazole is metabolically reduced by anaerobes. Studies have demonstrated that the reduced form of this drug interacts with DNA and provides the bactericidal action of metronidazole.

Indications

Animals:

Dirovet is indicated for the treatment of metritis, endometritis, vaginitis, trichomoniasis, giardiasis, gingivitis, amoebic dysentery, and calf scour.

The formulation also provides post-operative treatment following colonic surgery and inflammatory bowel disease (IBD).

Poultry:

Dirovet is additionally used for the management of histomoniasis, giardiasis, and trichomoniasis.

Benefits:

Dirovet is active against obligate anaerobic microorganisms, including both protozoa and bacteria.

The formulation also provides an anti-inflammatory effect in the bowel.

It additionally prevents inflammatory bowel disease by inducing non-specific immunity.

The product is absorbed rapidly from the gastrointestinal tract.

It can also be used alongside other antibiotics to treat mixed bacterial infections.

The formulation remains compatible with other antibiotics, including penicillin, aminoglycosides, and cephalosporins.

Dosage & Administration

Bolus Tablet:

Large Animal (Orally): 40–50 mg/kg body weight (i.e., 1 bolus per 40–50 kg body weight) for 5–7 days.

Large Animal (Intra-uterine): 4 boluses directly or powdered for douche per 100 kg body weight.

Poultry: 1 bolus per 3–6 L of drinking water for 4–6 days.

Powder for Solution:

Poultry: 1 g per 2–3 L of drinking water daily for 5 days.

Pigeon: 20 mg/kg once daily for 5 days or 50 mg/kg on alternate days for 3 treatments.

Livestock: 4 g/25 kg body weight daily for 5–7 days.

Or as directed by the registered veterinary physician.

Interaction

Dirovet bolus is reported to elevate prothrombin time in animals on warfarin or other coumarin anticoagulants. Cimetidine can interfere with the liver's ability to break down this bolus and the dose may have to be reduced. Phenobarbital and phenytoin may increase the metabolism of this bolus.

Contraindications

The drug should not be used in animals hypersensitive to active ingredients.

Side Effects

Usually, salivation, vomiting, decreased appetite, and gastrointestinal upset may occur.

Pregnancy & Lactation

This bolus should not be used in young puppies and kittens. This bolus should be avoided or used with caution, at reduced doses, in animals with kidney or liver disease.