Amilin® Plus Tablet: Each tablet contains Amitriptyline Hydrochloride BP 12.5 mg & Chlordiazepoxide Hydrochloride BP 5.609 mg equivalent to Chlordiazepoxide. 5 mg.
Amitriptyline is a tricyclic antidepressants. Chlordiazepoxide is in a group of drugs called benzodiazepines. Chlordiazepoxide affects chemicals in the brain that may become imbalanced and cause anxiety.
Mode of action:
Chlordiazepoxide is a benzodiazepine, exert its action in the central nervous system. The mechanism of action of amitriptyline is unknown, but the drug appears to interfere with the countless of norepinephrine into adrenergic nerve endings. This action may prolong the sympathetic activity of biogenic amines.
Amilin® Plus is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.
Amilin® Plus is recommended in an initial dosage of 3 or 4 tablets daily in divided doses; this may be increased to 6 tablets daily as required. Some patients respond to smaller doses and can be maintained on 2 tablets daily.
Concomitant use of tricyclic antidepressants with drugs that can inhibit cytochrome P450 2D6 may require lower doses than usually prescribed for either the tricyclic antidepressant or the other drug.
Over dosage:
Deaths may occur from overdose with this class of drugs. Multiple drug ingestion (including alcohol) is common in deliberate tricyclic antidepressant overdose. Signs and symptoms of toxicity develop rapidly after tricyclic antidepressant overdose; therefore, hospitalization is required as soon as possible.
Safe use of this drug during pregnancy and lactation has not been established.
Close supervision is required when this drug is given to hyperthyroid patients or those on thyroid medication. The usual precautions should be observed when treating patients with impaired renal or hepatic function. Patients with suicidal ideation should not have easy access to large quantities of the drug.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light.