Each capsule contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 500 mg.
Twicef® (Cefadroxil Monohydrate) is an orally active first generation cephalosporin antibiotic which is more effective against rapidly growing organisms forming cell walls. It acts by inhibiting mucopeptide synthesis in the bacterial cell wall, making it defective and osmotically unstable. Twicef® is bactericidal *in vitro* against a wide range of Gram-positive and Gram-negative microorganisms. Sensitive Gram-positive organisms include: penicillinase and non-penicillinase producing *Staphylococci*, beta-haemolytic *Streptococci*, *Streptococcus pneumoniae* and *Streptococcus pyogenes*. Sensitive Gram-negative organisms include: *E. coli*, *Klebsiella spp.*, *Proteus mirabilis*, *Moraxella (Branhamella) catarrhalis* and *Bacteroides spp.* (excluding *Bacteroides fragilis*) and some strains of *Haemophilus influenzae*.
Respiratory tract infections: Tonsillitis, pharyngitis, lobar and bronchopneumonia, acute and chronic bronchitis, pulmonary abscess, empyema, pleurisy, sinusitis, laryngitis, otitis media.
Skin and soft tissue infections: Lymphadenitis, abscesses, cellulitis, decubitus ulcers, mastitis, furunculosis, erysipelas.
Genitourinary tract infections: Pyelonephritis, cystitis, urethritis, gynaecological infections.
Other infections: Osteomyelitis, septic arthritis.
Route of administration:
Twicef® can be taken with meals or on an empty stomach.
Adults: 500 mg-1 g twice a day, depending on the severity of infection. Alternatively, in skin and soft tissue and uncomplicated urinary tract infections, 1 g once a day.
Children:
Elderly: Same as adult dose. No specific dosage recommendations or precautions for use in the elderly except to monitor those patients with renal impairment.
In the treatment of beta-haemolytic streptococcal infections, Twicef® should be administered for at least 10 days.
Renal impairment: In patients with renal impairment, the initial dose is 1000 mg of Twicef® and the maintenance dose (based on the creatinine clearance rate [ml/min/1.73m2]) is 500 mg at the time intervals listed below:
Creatinine Clearance (ml/min).
Dose Intrval (hrs).
0-10 ml/min.
36 hrs.
10-25 ml/min.
24 hrs.
No significant data are available.
The safety of Cefadroxil in the treatment of infections during pregnancy has not been established. Cephalosporin antibiotics are excreted in human breast milk and therefore, would be ingested by the neonate during breast feeding. Nursing mothers receiving Cefadroxil should discontinue breast-feeding.
Use in pregnancy and lactation: Cefadroxil is of pregnancy category B. Although there are no adequate and well controlled studies available in pregnant women, the drug can be used in pregnancy only if clearly needed. Cefadroxil is excreted in breast milk and should be used with caution in lactating mother.
Store below 30°C and dry places, protected from light. Keep all medicines out of reach of children.