Zimax® 250 Capsule: Each capsule contains Azithromycin 250 mg as Azithromycin Dihydrate USP. Zimax® 500 tablet: Each film coated tablet contains Azithromycin 500 mg as Azithromycin Dihydrate EP. Zimax® 15, 30 & 50 ml Dry Powder for Suspension: When reconstituted, each 5 ml suspension contains Azithromycin 200 mg as Azithromycin Dihydrate USP. Zimax® 500 Infusion: Each vial contains Azithromycin 500 mg as lyophilized powder of Azithromycin Dihydrate USP for intravenous infusion.
Zimax® is an azalide antibiotic, subclass of the macrolide class of antibiotics. Zimax® acts by binding to the 50s ribosomal subunit of susceptible organisms and thus interferes with microbial protein synthesis. Zimax® demonstrated activity in vitro, against a wide range of gram-positive and gram-negative bacteria including: *Staphylococcus aureus*, *Streptococcus pneumoniae*, *Streptococcus pyogenes* (Group A) and other Streptococcal species; *Haemophilus influenzae* and *parainfluenzae*; *Moraxella catarrhalis*; anaerobes including *Bacteroides fragilis*, *Escherichia coli*, *Bordetella pertussis*, *Bordetella parapertussis*, *Borrelia burgdorferi*, *Haemophilus ducreyi*, *Neisseria gonorrhoeae* and *Chlamydia trachomatis*. Zimax® also demonstrates activity in vitro against *Legionella pneumophila*, *Mycoplasma pneumoniae* and *hominis*; *Campylobacter sp.*, *Toxoplasma gondii* and *Treponema pallidum*.
Zimax® is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media and in skin and soft tissue infections. In sexually transmitted diseases in men and women, Zimax® is indicated in the treatment of non-gonococcal urethritis and cervicitis due to *Chlamydia trachomatis*.
Zimax® can be taken with or without food. To reconstitute Zimax® 15, 30, 50 ml powder for suspension, add 10, 20, 35 ml or 2, 4, 7 teaspoonful of just boiled and cooled water to the content of the bottle and shake well to mix uniformly.
Adults: For lower respiratory tract infections including bronchitis and pneumonia, upper respiratory tract infections including sinusitis and pharyngitis / tonsillitis, otitis media and skin and soft tissue infections, the total dose of Zimax® is 1.5 gm given as 500 mg once daily for 3 days. An alternative to this dosage schedule is that 500 mg once daily on day 1, followed by 250 mg once daily for next 4 days. For sexually transmitted diseases caused by *Chlamydia trachomatis*, the dose of Zimax® is 1 gm given as a single dose. Alternatively, 500 mg once daily on day 1, followed by 250 mg once daily for next 2 days may also be given.
Use in the elderly: Normal adult dosage is recommended.
Children: The dose of Zimax® in children over 6 months of age is 10 mg/kg body weight once daily for 3 days. Alternatively, 10 mg/kg on day 1, followed by 5 mg/kg for next 4 days is also recommended.
Body Weight (Age).
Volume ml (tea spoon).
Duration of treatment.
5-10 kg (6 months- 2 years).
1.25-2.5 ml (¼ -½ tsp).
Once daily for three days.
11-20 kg (.