Montene® 4 Tablet: Each orodispersible tablet contains Montelukast Sodium EP equivalent to Montelukast 4 mg.
Montene® 5 Tablet: Each orodispersible tablet contains Montelukast Sodium EP equivalent to Montelukast 5 mg.
Montene® 10 Tablet: Each film-coated tablet contains Montelukast Sodium EP equivalent to Montelukast 10 mg.
The cysteinyl leukotrienes (LTC₄, LTD₄, LTE₄) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene receptors (CysLT) found in the human airway.
Montelukast is an orally active compound that binds with high affinity and selectivity to the CysLT₁ receptor. Montelukast inhibits physiologic actions of LTD₄ at the CysLT₁ receptor without any agonist activity.
Montelukast is a leukotriene receptor antagonist indicated for:
By indications:
By age:
Montelukast may be administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma. In drug-interactions studies, the recommended clinical dose of montelukast did not have clinically important effects on the following medicinal products: theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin and warfarin.
Caution should be exercised, particularly in children, when montelukast is co-administered with phenytoin, phenobarbital and rifampicin.
Montelukast is classified as pregnancy category B. The drug has been shown to cross the placenta of pregnant rats and rabbits, but there have been no reports of its use in pregnant women. Montelukast is also known to be excreted into breast-milk, but only limited information is available on the significance of this finding. Caution should be used prior to initiating montelukast therapy in nursing mothers.
Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Patients should be advised to have appropriate rescue medication available.
Store below 30° C at a cool and dry place, away from light and moisture. Keep out of reach of children.