Xolamid® OSD Sterile Ophthalmic Suspension: Each ml contains Brinzolamide USP 10 mg.
Preservative Free.
Brinzolamide is a carbonic anhydride inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Mode of action Carbonic anhydride (CA) is an enzyme found in many tissues of the body including the eye. It catalyses the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. It exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II), found primarily in red blood cells, but also in other tissues. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport.
Brinzolamide is an inhibitor of carbonic anhydrase II with an in vitro IC50 of 3.2 nM and a Ki of 0.13 nM against carbonic anhydrase-II. Following topical ocular administration, brinzolamide inhibits aqueous humor formation and reduces elevated intraocular pressure. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss.
Ocular hypertension, or moderate open-angle glaucoma.
1 drop in the conjunctival sac of the affected eye(s) three times daily or as directed by the Physician.
Pregnancy Category C: It is not known whether this drug is excreted in human milk or not.
Glaucoma caused by accumulation of pigment particles in the drainage channels of the eye (pigmentary glaucoma).
Glaucoma caused as a result of a disorder of part of the eyeball called the ciliary body (pseudoexfoliative glaucoma). Diabetes, Contact lens wearers, Dry eyes.
Over dosage Although no human data are available, electrolyte imbalance, development of an acidic state, and possible nervous system effects may occur following oral administration of an overdose.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Do not freeze. Do not touch the dropper tip to surfaces since this may contaminate the suspension. Do not use after two month of first opening.