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Valarux

Tablet

500 mg

GENERIC NAMEValacyclovir

MANUFACTURED BYOpsonin Pharma Ltd.

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Available Pack Sizes:1 Size

Maximum Retail Price (MRP):

Quantity

৳ 361.35/ 1 g

16263

Composition

Valarux® 500 mg Tablet: Each film coated tablet contains Valarux® Hydrochloride USP 0.0625 mg equivalent to Valarux® 500 mg.

Valarux® 1 gm Tablet: Each film coated tablet contains Valarux® Hydrochloride USP 1.113 mg equivalent to Valarux® 1 gm.

Description

Valarux® (Valarux®) is an oral medication that is used to treat infections with herpes zoster (shingles), herpes simplex genitalis (genital herpes) & herpes labialis (cold herpes). It is a pro-herp, being coated with one of Acyclovir.

Mode of action Valarux® is an antiviral drug. After oral administration, Valarux® hydrochloride is rapidly absorbed from the gastrointestinal tract and nearly completely converted to Acyclovir and is active by first-pass intestinal action. Valarux® is a lipophilic analogue. OSHA polymerase inhibitor. Valarux® hydrochloride demonstrates antiviral activity against Herpes Simplex Virus type 1 (HSV-1) and type 2 (HSV-2) and Herula.

Pharmacokinetics After oral administration, Valarux® hydrochloride is rapidly absorbed from the gastrointestinal tract. The half-life and bioavailability (about 50%) than Acyclovir (10-20%). The binding of valarux® to human plasma proteins ranges from 13.5% to 17.7%. Valarux® is converted to acyclovir and is active by enzyme inhibitor under metabolic conditions. Acyclovir is converted to a small extent to inactive metabolites by aliphatic oxidase, by alcohol and catalytic demethylation.

Indications

Add Patients:

Cold Sore (Herpes Labialis).

Genital Herpes.

Intestinal Herpes.

Treatment of recurrent episodes in immunocompetent patients.

Treatment of recurrent therapy of recurrent episodes in immunocompetent or HIV-infected patients.

Reduction of inflammation of genital herpes.

Herpes zoster (shingles).

Pediatric Patients:

Cold Sore (Herpes Labialis).

Chikungunya.

Dosage & Administration

Adult:

Cold Sore (Herpes Labialis) 2 gm every 12 hours for 1 day.

Genital Herpes.

Acyclovir 1 gm twice daily for 10 days.

Recurrent episodes 500 mg twice daily for 3 days.

Herpes zoster (shingles) 1 gm once daily.

HIV-infected patients 500 mg twice daily.

Reduction of transmission 500 mg twice daily.

Herpes zoster (shingles) 1 gm 3 times daily for 7 days.

Pediatric:

Cold Sore (≥ 12 years) 2 gm every 12 hours for 1 day.

Chikungunya (≥ 6-18 years of age) 500 mg (3 times daily) for 5 days, (not to exceed 1 gm 3 times daily).

Interaction

No clinically significant drug-drug or drug-lipid interactions with Valarux® are known. Also dosages should be adjusted when Valarux® is administered with other antiviral and therapeutic solutions in subjects with normal renal function.

Contraindications

Valarux® is contraindicated in patients who are hypersensitive to Valarux® & Acyclovir or are exposed of the formulation.

Side Effects

The most common side effects are headache, nausea and abdominal pain.

The only adverse reaction reported in pediatric patients: 18 with a 18-year-old female.

Other hypersensitivity reactions include: hyperurhythmia, leucopenia, acute generalized exanthematous pustulosis, agranulocytosis, eosinophilia, confusion & decreased consciousness.

Pregnancy & Lactation

USFDA Pregnancy Category B. Valarux® should be administered to a nursing mother with caution and only when indicated.

Precautions & Warnings

Dosage reduction is recommended when administering Valarux® to patients with renal impairment. Dosing reduction should be made when administering to geriatric patients and patients receiving potentially nephrotic agents.

Storage Conditions

Store in the cool and dry place, protected from light.

Valarux • 1 g

৳ 361.35