Lora® 10 mg Tablet: Each tablet contains Loratadine USP 10 mg.
Lora® Suspension: Each 5 ml contains Loratadine USP 5 mg.
Indications: Seasonal allergic rhinitis, perennial allergic rhinitis, skin allergies including chronic urticaria.
Dosage & administration: Adults and children over 30 kg of body weight: 10 mg once daily, children under 30 kg or under 5 years of age: 5 mg once daily, children under 2 years: not recommended.
Contraindications: Hypersensitivity or idiosyncrasy to any component of Loratadine.
Use in pregnancy & lactation: US FDA pregnancy category C. Loratadine is excreted in the breast milk. So, it is not indicated to lactating mother.
Precautions: Severe hepatic impairment alters the pharmacokinetics of Loratadine and dose adjustment is required. Caution should be exercised when driving a car or operating potentially dangerous machinery.
Drug interactions: Concomitant use with Ketoconazole, Cimetidine, Nifedipine or Erythromycin may increase the plasma concentration of Loratadine.
Storage: Store in a cool and dry place, protected from light.
Loratadine (Lora ) is a non-sedative H1 receptor antagonist with antiallergic properties, devoid of anticholinergic activity. It is rapidly effective and long lasting antihistamine.
Mode of action:
Loratadine (Lora ) competitively antagonizes histamine at the H1 receptor site.
Pharmacokinetics:
Loratadine (Lora ) is widely absorbed (>90%) after oral administration. Mean plasma half-life is hours. There was no evidence of toxicity after administration of a maximal dose of 160 mg (single dose) or 40 mg twice daily for 28 days (multiple dose).The effect begins within 1-3 hours, reaches a maximum at 8-12 hours, and lasts for more than 24 hours. Loratadine (Lora ) is extensively and rapidly metabolized in the liver. Following a single oral administration of 40 mg, 27% of the dose is eliminated in the urine within the first 24 hours and over a 10 day period about 40% is excreted in the urine and 42% in the faeces.
Seasonal allergic rhinitis, perennial allergic rhinitis, skin allergies including chronic urticaria.
Adults and children over 30 kg of body weight: 10 mg once daily, children under 30 kg or under 5 years of age: 5 mg once daily, children under 2 years: not recommended.
Concomitant use with Ketoconazole, Cimetidine, Nifedipine or Erythromycin may increase the plasma concentration of Loratadine. Overdosage: There is little information on acute overdosage. Nausea, vomiting, hypotension, tachycardia, ataxia, and drowsiness have been reported.
US FDA pregnancy category C. Loratadine is excreted in the breast milk. So, it is not indicated to lactating mother.
Severe hepatic impairment alters the pharmacokinetics of Loratadine and dose adjustment is required. Caution should be exercised when driving a car or operating potentially dangerous machinery.
Store in a cool and dry place, protected from light. Packaging Lora 10 mg Tablet: Each carton contains 10X10 tablets in blister pack. Lora Suspension: Each carton contains a bottle having 60 ml suspension.
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