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Linexil

Film-coated Tablet

400 mg

GENERIC NAMELinezolid

MANUFACTURED BYOpsonin Pharma Ltd.

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Available Pack Sizes:3 Sizes

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 767.34/ 10 x 2

(Unit: ৳ 85.26 / 1 Tablet)

16263

Composition

Linexil® 400 mg Tablet: Each film coated tablet contains Linezolid USP 400 mg.

Linexil® 600 mg Tablet: Each film coated tablet contains Linezolid USP 600 mg.

Linexil® 100 ml Powder for Suspension: After reconstitution each 5 ml contains Linezolid USP 100 mg. Add 65 ml boiled purified water to reconstitute in 100 ml suspension.

Linexil® 300 ml IV Infusion: Each ml of supplied infusion contains Linezolid USP 2 mg.

Description

Linezolid is a synthetic antibacterial agent. It is bacteriostatic against *enterococci* and *staphylococci* and bactericidal against most strains of *streptococci*.

Mode of actionThe oxazolidinones are protein synthesis inhibitors: they stop the growth and reproduction of bacteria by disrupting translation of messenger RNA (mRNA) into proteins in the ribosome.

PharmacokineticsAbsorption: Rapidly and extensively absorbed after oral dosing. Maximum plasma concentrations are reached approximately 1 to 2 hours after dosing, and the absolute bioavailability is approximately 100%. Therefore, linezolid may be given orally or intravenously without dose adjustment.

Distribution: Linezolid readily distributes to well-perfused tissues. The plasma protein binding of linezolid is approximately 31%.

Metabolism: Hepatic oxidation of the morpholine ring, resulting in two inactive metabolites.

Elimination: Half-life elimination in adults 4-5 hours.

Indications

Vancomycin-Resistant *Enterococcus faecium* infections including cases with concurrent bacteremia.

Nosocomial pneumonia.

Complicated skin and skin structure infections.

Community acquired pneumonia including concurrent bacteremia.

Diabetic foot infection.

Dosage & Administration

Vancomycin- resistant *Enterococcus faecium* infections, including concurrent bacteremia: Adult (12 years and older)- 600 mg IV or 600 mg tablet 12 hourly for 14 to 28 days. Pediatric patients (birth through 11 years)- 10 mg/kg IV or oral 8 hourly for 14 to 28 days.

Nosocomial pneumonia, Complicated skin and skin structure infections, and Community acquired pneumonia, including concurrent bacteremia, Adult (12 years and older)- 600 mg IV or 600 mg tablet 12 hourly for 10 to 14 days Pediatric patients (birth through 11 years)- 10 mg/kg IV or 10 mg/kg oral 8 hourly for 10-14 days.

Uncomplicated skin and skin structure infections, Adult (12 years and older)- 400 mg 12 hourly for 10 to 14 days, adoloscent- 600 mg 12 hourly for 10 to 14 days. Pediatric patients (birth through 11 years)- less than 5 years- 10 mg/kg oral 8 hourly & incase of 5-11 years- 10 mg/kg oral 12 hourly for 10 to 14 days.

Interaction

Monoamine Oxidase inhibitor, Adrenergic agent, Serotonergic agent.

Over dosage Symptoms of a linezolid overdose may include weakness, or loss of balance or coordination.

Contraindications

Contraindicated for use in patients who have known hypersensitivity to Linezolid or any of the other product components.

Side Effects

Most of the adverse events reported with linezolid are mild to moderate in intensity.

The most common adverse events in patients treated with Linezolid were diarrhea, headache and nausea.

Pregnancy & Lactation

Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Precautions & Warnings

Myelosuppression has been reported and may be dependent on duration of therapy. Discontinue the treatment if Myelosuppression reported.

Storage Conditions

Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light.

Linexil • 10 x 2

৳ 767.34