Finix® MUPS 20 mg Tablet: Each enteric coated MUPS tablet contains Rabeprazole Sodium BP 20 mg.
Rabeprazole Sodium (Finix MUPS 20) is an antiulcerant drug in the class of Proton Pump Inhibitor.
Pharmacokinetics:
Rabeprazole suppresses gastric acid secretion by inhibiting the gastric enzyme at the secretory surface of the gastric parietal cell. Rabeprazole is absorbed and can be detected in plasma by 1 hour. The effects of food on the absorption of Rabeprazole have not been evaluated. Rabeprazole is 96.3% bound to human plasma proteins. Approximately 90% of Rabeprazole is eliminated in the urine. The remainder of the dose is excreted in the feces.
Disease.
Dosage & Frequency.
Treatment duration.
Healing of erosive or ulcerative Gastro Esophageal Reflux Disease (GERD).
20 mg once daily.
4 to 8 weeks; patients have not healed after 8 weeks of treatment, an additional 8 week course may be considered.
Maintenance of healing of erosive or ulcerative GERD.
20 mg once daily.
Treatment of Symptomatic GERD.
20 mg once daily.
4 weeks; If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.
Healing of Duodenal Ulcer.
20 mg once daily.
4 weeks; If symptoms do not resolve completely after 4 weeks, an additional course of treatment may be considered.
Treatment of Pathological Hyper secretory Conditions, including Zollinger-Ellison Syndrome.
60 mg once daily.
Doses should be adjusted to individual patient needs and should continue for as long as clinically indicated.
Disease.
Dosage & Frequency.
Treatment duration.
Treatment of GERD in pediatric patients 1 to 11 years of age (Less than 15 kg).
5 mg once daily.
12 weeks with the option to increase to 10 mg if inadequate response.
Treatment of GERD in pediatric patients 1 to 11 years of age (15 kg or more).
10 mg once daily.
12 weeks.
Helicobacter pylori Eradication to Reduce the Risk of Duodenal Ulcer Recurrence:
Drug.
Dose:
Duration.
Rabeprazole Sodium.
20 mg.
Twice Daily for 7 Days.
Amoxicillin.
Rabeprazole is metabolized by the Cytochrome P-450 (CYP-450) drug metabolizing enzyme system. Rabeprazole does not have clinically significant interactions with other drugs metabolized by the CYP-450 system, such as Warfarin, Theophylline, Diazepam and Phenytoin etc.
Over dosage: There has been no experience with large overdoses with Rabeprazole. In the event of overdosage, treatment should be symptomatic and supportive.
Rabeprazole should be used in only if the potential benefit justifies the potential risk to the fetus. There are no data on the excretion of Rabeprazole into the breast milk. But due to many medicine excreted through the breast milk, so.
must be taken during lactation period.
Administration of Rabeprazole Sodium to patients with mild to moderate liver impairment resulted in increased exposure and decreased elimination. Caution should be exercised in patients with severe hepatic impairment.
Store in a cool (below 25 C temperature) and dry place, protected from light.