Cazep® 200 mg Tablet: Each tablet contains Carbamazepine BP 200 mg.
Cazep® CR 200 mg Tablet: Each controlled release tablet contains Carbamazepine BP 200 mg.
Cazep® 100 ml Suspension: Each 5 ml contains Carbamazepine BP 100 ml.
Indications: Epilepsy (All forms of epilepsy except myoclonic and absence seizures), trigeminal neuralgia, mood disorder, aggression and diabetic insipidus.
Carbamazepine (Cazep ) is an iminodibenzyl derivative with anticonvulsant properties and its structure is related to the tricyclic antidepressants.
Mode of action:
Carbamazepine (Cazep ) has a wide range of pharmacological effects in animals and humans. The anticonvulsant effects of Carbamazepine are more pronounced against electroshock seizures than against chemically induced seizures. Carbamazepine reduces the generation of high frequency repetitive firing by blocking sodium channels in a use and_ frequency-dependant manner. This is thought to be its main mode of action, although it also reduces sodium and calcium flux through N-methyl-D-asparate (NMDA)-activated glutamate receptor sites. In addition, it blocks the reuptake of norepinephrine into presynaptic terminals and has adenosine receptor antagonistic effects.
Pharmacokinetics:
The gastrointestinal absorption of Carbamazepine (Cazep ) in humans has been estimated at between 72% and 96% with peak plasma concentrations occurring between 6 and 24h. Carbamazepine is lipophilic and once in the circulation it rapidly penetrates through cell membranes to gain access to various body tissues. The concentration of Carbamazepine in brain is similar to that found in plasma. Carbamazeine is about 54%-80% bound to plasma protein. The plasma half-life following a single dose is 30-40 hrs whereas on multiple dosing it is 11.7 hr. Carbamazepine is extensively metabolized in the liver with only about 1% of the administered dose excreted in urine in the unchanged form.
Epilepsy (All forms of epilepsy except myoclonic and absence seizures), trigeminal neuralgia, mood disorder, aggression and diabetic insipidus.
Women using oral contraceptive pills may become pregnant during therapy with Carbamazepine. Carbamazepine, like any other psychoactive drug may reduce the patient s tolerance to alcohol. Carbamazepine has been observed to shorten the half-life of doxycycline. Clarithromycin, erythromycin, INH, and fluoxetine increase plasma concentration of Carbmazepine.
Plasma concentration of Carbamazeine decreases during pregnancy. Therefore increased dose of carbamezepine is suggesting during . Beast feeding is not contraindicated. This drug should be used in pregnancy and lactation if absolutely needed.
Cardiovascular disease, hepatic or renal disorders, changing treatment from Carbamazepine to another antiepileptic drug, hematological disorders and glaucoma.
Keep out of reach of children. Store in a dry place, below 25 C temperature and protected from light.