Each tablet contains Itraconazole USP 200 mg. Azonox 100 mg Capsule: Each capsule contains Itraconazole pellets 22% Ph. Gr. 454.545 mg equivalent to Itraconazole USP 100 mg.
Itraconazole (Azonox ) is an orally active triazole antifungal agent that has broad-spectrum of activity against wide range of pathogenic fungus.
Mode of action:
Itraconazole inhibits cytochrome P-450 dependent enzymes resulting in impairment of the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells.
Pharmacokinetics:
Itraconazole is rapidly absorbed after oral administration. Peak plasma concentrations of Itraconazole are reached within 2 to 5 hours following oral administration. The terminal half-life of Itraconazole generally ranges from 16 to 28 hours after single dose. Bioavailability of itraconazole is about 55%. Most of the itraconazole in plasma is bound to protein approximately 99.8%.
Itraconazole (Azonox ) is used for the treatment of Tinea corporis, Tinea cruris, Tinea pedis, Tinea manus, Vulvovaginal candidiasis, Fungal keratitis, Pityriasis versicolor, Oropharyngeal candidiasis, Onychomycosis, Histoplasmosis, Systemic Infections: (Aspergillosis, Candidiasis and Cryptococcal Meningitis when other drugs are Antifungal prophylaxis: To prevent systemic fungal infection in severely neutropenic patients.
Itraconazole (Azonox ) inhibits the metabolism of Cyclosporine and Warfarin. with Terfenadine, Phenobarbitone and Midazolam has been reported.
Over dosage: There is no experience of over dosage with Itraconazole.
Not recommended during pregnancy & lactation, unless otherwise indicated by the physician.
Hepatic enzyme value should be monitored in patients with preexisting hepatic function abnormalities. It should also be done periodically in all patients receiving continuous treatment for more than one month or at any time a patients develops sign and symptoms suggestive liver dysfunction.
Keep out of reach of children. Store in a dry place, below 25 C temperature and protected from light.