Alistin® EF Tablet: Each effervescent tablet contains Acetylcysteine USP 600 mg.
Acetylcysteine is the metabolic byproduct of cysteine. As it is an effervescent tablet, it melts very fast and absorbs more. As a result, its presence in the body is higher.
Mode of action:
Acetylcysteine and its metabolic byproduct cysteine exert its mucolytic action through its free sulfhydryl (-SH) group, which reduces the disulfide bonds in the mucus matrix and lowers mucus viscosity.
Pharmacokinetics:
After oral administration, acetylcysteine is rapidly and almost completely absorbed for conversion and is metabolized by the liver. Protein binding of Acetylcysteine is almost 50%. Its plasma half-life is 1 hour which is determined by hepatic first pass metabolism.
Acute and chronic bronchopulmonary disorders e.g. Pneumonia, Bronchitis, Tracheobronchitis, Chronic asthmatic bronchitis, Tuberculosis, Primary amyloidosis of the lung.
Acetylcysteine is also indicated in the treatment of Paracetamol overdose.
6 years and above: 1 effervescent tablet daily (Preferably in the evening). The duration of treatment should be 5-10 days in acute treatment. In case of chronic condition, treatment duration can be increased upto 6 months as per physician’s advice.
Dissolve 1 effervescent tablet in a glass of water (200 ml) to drink.
After taking Acetylcysteine orally it increases the bioavailability of Amoxicillin, but shows no effect on Doxycycline and reduces the absorption of Cefalexin. Acetylcysteine seems to increase the effects of Nitroglycerin.
Over dosage:
Accidental overdose of Acetylcysteine may cause nausea, vomiting or diarrhea.
USFDA Pregnancy Category B. Caution should be taken in case of pregnancy & lactation while using Acetylcysteine.
Caution should be taken in case of patients suffering from Asthma.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light.