Pileus 50: Each capsule contains Fluconazole USP 50 mg.
Pileus 150: Each capsule contains Fluconazole USP 150 mg.
Pileus is a synthetic trisazole antifungal drug that inhibits the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells, leading to abnormalities in membrane permeabilities, inhibition of growth, abnormal cell wall formation and accumulation of intracellular lysis and membranous vesicles. It is active against a broad spectrum of yeast and other fungal pathogens. Following oral administration, absorption is rapid with > 90% of the dose being absorbed. Bioavailability is the same whether taken during fasting or with food, as the pharmacokinetics of Fluconazole are relatively unchanged and 11% is a direct metabolite of the metabolites in the urine, presumably as a result of metabolism in the liver. A further 2% of a dose is recovered unchanged in the feces, and the fate of the remaining is unknown.
Fluconazole is usually given orally. Generally the total daily dose is given at once unless nausea supervenes, in which case the dose may be divided.
In the medical: Fluconazole decreases the metabolism of Cyclosporine and Phenytoin and increases the AUC of Retinol and Acufozine increases bleeding time in patients treated with Warfarin. Concomitant use of Fluconazole decreases in the mean plasma clearance of theophyllin and warfarin, and increases the mean plasma concentration of Oral hypoglycemic, Ridamipan reduces the metabolism of Fluconazole.
With food & others: Avoid milk, milk products, iron-containing products, or antacids containing calcium, magnesium, and aluminum one hour before or 2 hours after taking these medications.
Over dosage:
In the case of an overdose, supportive measures should be instituted.
Pregnancy: There are limited data on the use of Fluconazole in pregnant woman. However Fluconazole should be used in pregnancy only when the benefit clearly outweighs the risk.
Lactation: Fluconazole is excreted in breast milk in levels comparable to those of breast milk in plasma. Therefore, the drug should be avoided during lactation.
Fluconazole is relatively safe for pediatric patients. Hepatotoxicity and gastrointestinal toxicity are the most common adverse events. It is important to be aware that drug interactions with Fluconazole can result in significant toxicity.
Caution should be taken in renal impairment; in hepatic disease liver function should be monitored and should be discontinued if signs or symptoms of hepatic disease appear.
Store within 30° C temperature and cool and dry place, away from light. Keep out of the reach of children.