Nidozox 500 Tablet: Each film-coated tablet contains Nitazoxanide INN 500 mg.
Nidozox 30 ml Powder for Suspension: After reconstitution each 5 ml suspension contains Nitazoxanide INN 100 mg.
Nidozox (Nitazoxanide) is a synthetic antiprotozoal agent and is well absorbed from GIT. The Antiprotozoal activity of Nitazoxanide is believed to be due to interference with the pyruvate ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction which is essential to anaerobic energy metabolism. Following oral administration in human, Nitazoxanide is rapidly hydrolyzed to an active metabolite, Izzoxanide (deacylated-Nitazoxanide), which is readily reduced by PFOR enzymes from the parasites by transfer of electrons. This reduced form of Nitazoxanide deprives parasite of their energy and eradicates them from body.
The suspension or tablet should be taken with food.
OR AS DIRECTED BY THE PHYSICIAN.
Nitazoxanide is highly bound to plasma protein (>99.9%). Therefore, caution should be used when administering Nitazoxanide concurrently with other highly plasma protein-bound drugs.
Over Dosage:
Information on Nitazoxanide over dosage is not available. Single oral dose of up to 4000 mg Nitazoxanide have been administered to healthy adults without significant adverse effects.
Directions for Reconstitution of Suspension:
First shake the bottle to loosen powder. Add 22.5 ml (by using supplied measuring cup) boiled and cooled water into the bottle. Shake the bottle to disperse the powder completely. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool place and used within 7 days of preparation.
Shake the bottle well before each use.
Pregnancy Category B: This drug should be used during pregnancy only if clearly needed. It is not known whether Nitazoxanide is excreted in human milk. As many drugs are excreted in human milk, caution should be exercised when Nitazoxanide is administered to a nursing mother.
Nitazoxanide should be administered with caution to patients with hepatic, renal and biliary disease.
Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.