Furotil Plus® 125 mg Tablet: Contains Cefuroxime Axetil (equivalent to Cefuroxime 125 mg) and Potassium Clavulanate (equivalent to Clavulanic Acid 31.25 mg).
Description:
Cefuroxime Axetil is a second generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. It exerts its bactericidal effect by binding to an enzyme penicillin-binding proteins (PBPs) involved in bacterial cell wall synthesis. This binding results in inhibition of bacterial cell wall synthesis and subsequent cell death. Clavulanic acid is a beta Lactamase Inhibitor. It is a suicidal inhibitor of beta-lactamase enzymes from Streptomyces clavuligerus. It contains a beta-lactam ring and binds strongly to beta-lactamase at or near its active site, thereby hindering enzymatic activity.
Pharmacology:
Cefuroxime Axetil is a second-generation cephalosporin antibiotic that kills bacteria by inhibiting cell wall synthesis.
Clavulanic Acid is a beta-lactamase inhibitor that protects cefuroxime from bacterial resistance mechanisms by inactivating beta-lactamase enzymes.
• Pharyngitis/Tonsillitis
• Acute Bacterial Otitis Media
• Acute Bacterial Maxillary Sinusitis
• Chronic Bronchitis Exacerbations
• Uncomplicated Skin and Skin-Structure Infections
• Urinary Tract Infections
• Uncomplicated Gonorrhea
• Early Lyme Disease
• Impetigo
Route: Oral
Tablets: Can be taken with or without food.
Suspension: Recommended to be taken with food.
For Adults & Pediatric Patients (13 years and older)
Pharyngitis/Tonsillitis (mild to moderate): 250 mg every 12 hours for 10 days.
Chronic Bronchitis Exacerbation (mild to moderate): 250 or 500 mg every 12 hours for 10 days.
Uncomplicated Skin Infections: 250 or 500 mg every 12 hours for 10 days.
Urinary Tract Infections: 250 mg every 12 hours for 7 to 10 days.
Gonorrhea: 1,000 mg single dose.
Early Lyme Disease: 500 mg every 12 hours for 20 days.
For Pediatric Patients (3 months to 12 years) - Oral Suspension
Acute Otitis Media/Sinusitis/Impetigo: 30 mg/kg every 12 hours for 10 days (Maximum dose 1,000 mg).
Overdose:
May cause convulsions or encephalopathy. Dialysis can reduce cefuroxime levels.
Use cautiously in pregnancy, especially during the first trimester.
Cefuroxime is excreted in breast milk, so consider discontinuing breastfeeding during treatment.
Hypersensitivity Reactions: Discontinue use immediately if severe reactions occur.
Clostridium difficile-associated Diarrhea (CDAD): Monitor for diarrhea and evaluate for CDAD if necessary.
Common Side Effects
Diarrhea, nausea/vomiting, and taste disturbances.
Rare: Headache, dizziness, transient increases in liver enzymes.
Tablets: Store in a dry place at temperatures not exceeding 25°C. Protect from light and moisture.
Suspension: Store reconstituted suspension in a refrigerator (2-8°C) and use within 7 days. Unreconstituted powder should be stored in a dry place at temperatures not exceeding 25°C.