F-Zol 50: Each capsule contains 50 mg fluconazole USP.
F-Zol 150: Each capsule contains 150 mg fluconazole USP.
F-Zol 200: Each capsule contains 200 mg fluconazole USP.
F-Zol suspension: Each 5ml suspension contains 50mg fluconazole USP.
F-Zol (Fluconazole) the first of a new subclass of synthetic triazole antifungal agents. It is a potent and selective inhibitor of fungal cytochrome P450 dependent enzymes necessary for the synthesis of ergosterol. Bioavailability of Fluconazole is over 90%. Its pharmacokinetic properties are similar following administration by the intravenous or oral route. Unlike Ketoconazole and Itraconazole its absorption is not dependent on gastric acidity. Fluconazole is widely distributed in the body and persist long time in tissue so clinical cure may be achieved after withdrawal of treatment.
*Prescription only*
Protein binding of Fluconazole is minimal which precludes its many adverse drug interaction. It is much less active against mammalian P450 enzymes; still potential exists for interaction with drugs that are metabolized by P450.
Fluconazole increases the plasma concentration of theophylline, carbamazepine and sulphonylureas. Effect of anticoagulants increases by Fluconazole. Plasma concentration of fluconazole reduced by Rifampicin. Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents, blood glucose concentration should be monitored and doseshould be adjusted with sulfonylurea and other hypoglycemic agent.
Caution should be taken in patients with renal impairment, pregnancy, Lactating mother and in raised liver enzyme. In lactating mother Fluconazole is present in milk but amount is too small to be harmful.
Store at below 30°C in a dry place protected from light. Keep out of reach of children.