Denicol Eye Drops: Each ml contains Dexamethasone 0.1% as Sodium Phosphate BP and Chloramphenicol 0.5% BP.
Denicol ® is an ophthalmic preparation of Dexamethasone and Chloramphenicol. Dexamethasone is one of the most potent corticosteroids. It has anti-inflammatory and anti-allergic action. Chloramphenicol is a broad spectrum anti-biotic which acts against both Gram Positve and Gram Negative bacteria and other microorganisms. This combination yields excellent results in inflammation of the anterior uvea (iritis, iridocyclitis)
Denicol ® one or two drops into the conjuctival sac every hour during the day and every two hours during the night as initial therapy. When a favorable response in observed reduce the dose to one drop every 4 hours. Later, further reduction of dosage to one drop 3 or 4 times daily may sufficient to control the symptoms.
Systemic absorption may reduce efficacy of antidiabetic drugs; CYP3A4 inhibitors increase dexamethasone levels; chloramphenicol may prolong elimination of phenytoin.
Denicol® is contraindicated in fresh herpes simplex cornealis, tubercular process involving the conjunctiva, the cornea and the anterior uvae.
Common: Slight ocular burning sensation. Less Common: Reversible increase in intraocular pressure, cataract, corneal softening.
Overdose
No Data
Category C. Chloramphenicol and corticosteroids carry theoretical risks; use ophthalmic preparation only if benefit justifies fetal risk. Lactation: Excretion in human milk unknown; consult physician before use.
Store below 25°C in a cool, dry place. Protect from light. Keep out of reach of children.