Cox-E 60 mg Tablet: Each film coated tablet contains 60 mg Etoricoxib INN.
Cox-E 90 mg Tablet: Each film coated tablet contains 90 mg Etoricoxib INN.
Cox-E 120 mg Tablet: Each film coated tablet contains 120 mg Etoricoxib INN.
Etoricoxib is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic activities. It is a potent, orally active, highly selective cyclooxygenase-2 (COX-2) inhibitor within and above the clinical dose range. COX-2 has been shown to be primarily responsible for the synthesis of prostanoid mediators of pain, inflammation and fever. Selective inhibition of COX-2 by Etoricoxib decreases these clinical signs and symptoms with decreased GI toxicity and without effects on platelet function.
Acute pain & inflammation, osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis (AS), acute gouty arthritis, chronic musculoskeletal pain, dysmenorrhoea.
Etoricoxib is administered orally. Etoricoxib may be taken with or without food. Do not halve tablet.
Adult & adolescent (over 16 years):
Etoricoxib 120 mg should be used only for the acute symptomatic period, limited to a maximum of 8 days treatment.
*Prescription only*
At high dose Etoricoxib may have interaction with Warfarin, Methotrexate, ACE inhibitors, Lithium & Aspirin.
As with other drugs known to inhibit prostaglandin synthesis, use of it should be avoided in late pregnancy because it may cause premature closure of the ductus arteriosus. It should be used during the first two trimesters of pregnancy only if the potential benefit justifies the potential risk to the foetus. It is not known whether this drug is excreted in human milk.
In clinical studies, administration of Etoricoxib at single doses up to 500 mg and multiple doses up to 150 mg/day for 21 days did not result in significant toxicity. In the event of overdose, it is reasonable to employ the usual supportive measures, e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.
A patient with decreased liver & kidney function, dehydration, hypertension, heart failure, GI perforation & patients over 65 years of age.
Store at below 30°C in a dry place protected from light. Keep out of reach of children.