Cerox-A 250mg tablet: Each tablet contains Cefuroxime 250mg as Axetil USP.
Cerox-A 500mg tablet: Each tablet contains Cefuroxime 500mg as Axetil USP.
Cerox-A Powder for suspension: Each 5ml contains 125mg of Cefuroxime as Axetil USP.
Cerox-A 250mg IM/IV Injection: Each vial contains Cefuroxime 250mg as Sodium USP.
Cerox-A 750mg IM/IV Injection: Each vial contains Cefuroxime 750mg as Sodium USP.
Cerox-A 1.5g IV Injection: Each vial contains Cefuroxime 1.5g as Sodium USP.
Cerox-A ® is a preparation of Cefuroxime. It is a semi synthetic, broad spectrum Cephalosporin antibiotic for oral and parenteral administration; which is active against a wide range of gram-positive and gram-negative organisms including many β- lactamase producing strains.
Oral Infections Dosage Duration(Days)
Tablet: Adolescents and adults (13 years of age and above):
Pharyngitis, Tonsillitis: 250 mg b.i.d for 5-10 days
Acute bacterial maxillary sinusitis: 250 mg b.i.d for 10 days
Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d for 10 days
Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d for 5-10 days
Uncomplicated skin and skin-structure infections: 250-500 mg b.i.d for 10 days
Uncomplicated urinary tract infections: 125-250 mg b.i.d for 7-10 days
Uncomplicated gonorrhea: 1000 mg once
Lyme disease: 500 mg b.i.d for 20 days
Tablet: Pediatric Patients up to 12 years (Who can swallow tablets):
Pharyngitis, Tonsillitis: 125 mg b.i.d for 5-10 days
Acute otitis media: 250 mg b.i.d for 10 days
Acute bacterial maxillary sinusitis: 250 mg b.i.d for 10 days
Suspension: Paediatric patients (3 months – 12 years):
Pharyngitis, Tonsillitis: 20 mg/kg/day in 2 divided doses for 5-10 days
Acute otitis media: 30 mg/kg/day in 2 divided doses for 10 days
Acute bacterial maxillary sinusitis: 30 mg/kg/day in 2 divided doses for 10 days
Injection Adults: Usual dose is 750mg three times daily by IM or IV injection for 5-10 days. For more severe infections 1.5g three times daily IV. Frequency may be increased to 6-hourly giving total daily doses of 3g to 6g. Pre-operative prophylaxis: 1.5 g IV just before surgery (approx 0.5-1 hr before incision), thereafter 750 mg IV every 8h for prolonged procedures. Open heart surgery: 1.5 g IV at induction and every 12h thereafter for total 6 g. Bone and joint infections: 1.5 g every 8h. Life-threatening infections: 1.5 g every 6h. Bacterial meningitis: max 3 g every 8h. Gonorrhea: 1.5g single dose (two 750 mg injections into 2 sites).
Infants and children (Above 3 months of age): Usual dose 30-100mg/kg/day in 3-4 divided doses (60 mg/kg/day for most infections). Neonates: 30-100mg/kg/day in 2-3 divided doses. Bone and joint infections: 150 mg/kg/day in divided doses every 8h. Bacterial meningitis: 200-240 mg/kg/day IV in divided doses every 6-8h.
Preparation of solution for Injection:
Cerox-A ® 1.5g IV: Reconstitute with 16.0 ml WFI
Cerox-A ® 750mg IV: Reconstitute with 8.0 ml WFI
Cerox-A ® 750mg IM: Reconstitute with 3.0 ml WFI
Cerox-A ® 250mg IV: Reconstitute with 2.0 ml WFI
Cerox-A ® 250mg IM: Reconstitute with 1.0 ml WFI
Preparation of Powder for suspension: Shake bottle well to loosen powder. Add 40ml (8 spoonfuls) boiled and cooled water in two portions. Shake vigorously. Keep tightly closed, store in refrigerator, use within 14 days.
Probenecid reduces renal tubular clearance; increases carbamazepine plasma concentrations (monitor carbamazepine levels); oral anticoagulants show increased prothrombin time/INR.
Cefuroxime is contraindicated in patients with known hypersensitivity to Cephalosporins & patients with pseudomembraneous colitis.
Common: Nausea, vomiting, diarrhea, abdominal discomfort, abdominal pain. Rare: Overgrowth of non-susceptible microorganisms, pseudomembranous colitis.
Overdose
Over dosage of Cefuroxime can cause cerebral irritation leading to convulsions. Serum levels of Cefuroxime can be reduced by haemodialysis and peritoneal dialysis.
Category B (Avoid in 1st trimester). Safely used in 2nd and 3rd trimesters for bacterial infections; avoid in 1st trimester if possible. Lactation: Excreted in breast milk; caution advised.
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.