Brodil Accucap: Each Acucap capsule contains 200 mcg of Salbutamol BP (as Sulfate).
Brodil ® Accucap dry powder inhaler is a preparation of Salbutamol sulfate. Salbutamol is a relatively selective ß 2 adrenoreceptor stimulant. It is more specific than both isoprenaline and orciprenaline for adrenergic ß 2 receptors. Salbutamol is a sympathomimetic agent which has a highly selective action on ß adrenergic receptors in bronchial muscle. It provides short-acting (4 to 6 hour) bronchodilation with fast onset (within 5 minutes) in reversible airway obstruction. ß 2 adrenoceptor agonist is used in the treatment of asthma and other forms of diffuse reversible airways obstruction.
Brodil ® Accucap inhaler is administered by the inhaled route only. It is suitable for patients including those who cannot use metered dose inhaler successfully. Adults For the relief of acute bronchospasm and for managing intermittent episodes of asthma: one or two (200-400 mcg) Brodil ® Accucap as a single dose. For chronic maintenance or prophylactic therapy: one or two (200-400 mcg) Brodil ® Accucap up to four times daily. For prevention of exercise induced bronchospasm: two (400 mcg) Brodil ® Accucap before exertion. Elderly The dosage is same as that for adults. Children For the relief of acute bronchospasm, management of episodic asthma and for prevention of exercise induced bronchospasm: one (200 mcg) Brodil ® Accucap may be administered as a single dose. For routine maintenance and prophylaxis: one (200 mcg) Brodil ® Accucap up to four times daily
Non-selective beta-blockers (propranolol) inhibit bronchodilator effect and induce severe bronchospasm; non-potassium-sparing diuretics (loop and thiazide) exacerbate hypokalemia; halogenated anesthetics increase cardiac arrhythmia risk; MAO inhibitors and tricyclic antidepressants potentiate cardiovascular effects.
Salbutamol inhaler is contraindicated in patients with a history of hypersensitivity to any of its components. Although intravenous salbutamol is used in the management of premature labour, salbutamol inhaler preparations are not appropriate for managing premature labour or threatened abortion during the first or second trimesters of pregnancy.
Less Common: Tremor, headache. Rare: Muscle cramps, angioedema, urticaria, bronchospasm, hypotension, paradoxical bronchospasm.
Overdose
As with all sympathomimetic inhaler medications, cardiac arrest and even death may be associated with abuse. The preferred antidote for overdose with salbutamol inhaler is cardioselective beta-blocker, such as metoprolol tartarate. But beta-blockers should be used with caution in patients with a history of bronchospasm. Dialysis is not appropriate treatment for overdose of Salbutamol inhaler.
Category C. Crosses placental barrier; use in pregnancy only if maternal benefit outweighs fetal risk; contraindicated in threatened abortion. Lactation: Secreted into breast milk; breastfeeding is not recommended.
Store below 30°C in a dry place. Protect from moisture and heat. Do not swallow Acucap capsules. Keep away from children.