Atasin 10 tablet: Each coated tablet contains Atorvastatin 10 mg as Calcium USP.
Atasin 20 tablet: Each coated tablet contains Atorvastatin 20 mg as Calcium USP.
Atasin 40 tablet: Each coated tablet contains Atorvastatin 40 mg as Calcium USP.
Atasin 80 tablet: Each coated tablet contains Atorvastatin 80 mg as Calcium USP.
Atasin ® is a preparation of Atorvastatin which is a lipid-lowering agent. It's a selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3- hydroxy-3-methylglutaryl-coenzyme A to Mevalonate, a precursor of sterols, including cholesterol. Cholesterol and triglycerides circulate in the bloodstream as part of lipoprotein complexes. Elevated plasma levels of total cholesterol (total-C), LDL-cholesterol (LDL-C), and apolipoprotein B (Apo B) promote human atherosclerosis and are risk factors for developing cardiovascular disease, while increased levels of HDL-C are associated with a decreased cardiovascular risk.
Atasin EZ should be taken in oral route with or without food at any time of the day. Tablets should not be crushed, dissolved or chewed.
The dosage range of Atasin® EZ is 10/10 mg to 80/10 mg daily. The recommended starting dose is 10/10 mg or 20/10 mg daily. The recommended starting dose for patients who require a larger reduction in LDL-C (greater than 55%) is 40/10 mg daily. After initiation and/or upon titration of this medicine, lipid levels should be analyzed within 2 or more weeks and dosage adjusted accordingly. The dosage in patients with homozygous familial hypercholesterolemia is 40/10 mg or 80/10 mg daily.
Strong CYP3A4 inhibitors (clarithromycin, itraconazole, protease inhibitors) significantly increase atorvastatin exposure and rhabdomyolysis risk; cyclosporine, gemfibrozil, and fibrates heighten myopathy risk; CYP3A4 inducers (rifampin, efavirenz) reduce plasma concentrations; increases digoxin and oral contraceptive levels.
Atorvastatin is contraindicated in patients who are hypersensitive to any component of this product or to any of its ingredients. It is also contraindicated in patients with active liver disease, which may include unexplained persistent elevations in hepatic transaminase levels.
Common: Nasopharyngitis, arthralgia, diarrhea, myalgia, pain in extremity, urinary tract infection.
Overdose
There is no specific treatment for Atorvastatin overdosage. In the event or an overdose, the patient should be treated symptomatically, and supportive measures instituted as required. Due to extensive clrug binding to plasma proteins, hemodialysis is not expected to significantly enhance Atorvastatin clearance.
Category X (Contraindicated). Potential for serious fetal damage; strictly contraindicated in women who are or may become pregnant. Lactation: Statins pass into breast milk; breastfeeding is strictly contraindicated.
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.