Sonexa-C Sterile Eye Drops: Each ml contains Chloramphenicol BP 5 mg and Dexamethasone Phosphate USP 1 mg.
Chloramphenicol is a bacteriostatic antibiotic with a broad spectrum of action against both Gram-positive and Gram-negative bacteria as well as some other organisms. Dexamethasone is a glucocorticoid. It has an anti-inflammatory and anti-allergic action. It is used topically in the treatment of inflammatory conditions of the anterior segment of the eye. It is also effective post-operatively.
For steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial ocular infection exists. For inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitis is accepted to obtain a diminution in oedema and inflammation. For chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies. It is also effective postoperatively.
It is contraindicated in fungal, viral, tuberculous and other infections of the eye and in glaucoma. It is also contraindicated in patients hypersensitive to any component of this product. The use of anti-infective and steroid is always contraindicated after uncomplicated removal of a corneal foreign body.
Blood dyscrasias have been reported in association with the local use of chloramphenicol. Allergic sensitization may occur with the local use of chloramphenicol. Elevation of intraocular pressure with possible development of glaucoma, and infrequent optic nerve damage, posterior subcapsular cataract formation, and delayed wound healing may occur with the use of steroid. Secondary infection has occurred after long term use of combinations containing steroid and antimicrobial. Fungal infections of the cornea are particularly prone to develop with the long term application of steroid. Secondary bacterial ocular infection following suppression of host responses also occur.
Use in pregnancy: Although there is no evidence of teratogenic effects with the use of Ketotifen in pregnancy, use of Ketotifen should be avoided in pregnancy.
Use in lactation: Ketotifen is excreted in breast milk; therefore mothers receiving Ketotifen should not breastfeed.
Prolonged use of steroid containing product may result in posterior subcapsular cataract formation and glaucoma with optic nerve damage. Intraocular pressure monitoring is needed. It delays wound healing. The prolonged use of antibiotics may occasionally result in over growth of non-susceptible organisms, including fungi. If new infections appear during treatment, the drug should be discontinued and appropriate measures should be taken.
Keep unopened bottle at 2-8 C. After opening keep the bottle in a dry place below 25 C. Should be dispensed only on the prescription of a registered physician. Do not use longer than 30 days after first opening. Keep out of the reach of children.