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Human

Sabicard

Tablet

24 mg + 26 mg

GENERIC NAMESacubitril + Valsartan

MANUFACTURED BYAristopharma Ltd.

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Available Pack Sizes:3 Sizes

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 405.00/ 10's

(Unit: ৳ 45.00 / 1 Tablet)

16263

Composition

Sabicard 50 Tablet: Each film coated tablet contains Sacubitril Valsartan Sodium Hemipentahydrate INN equivalent to Sacubitril 24 mg & Valsartan 26 mg.

Sabicard 100 Tablet: Each film coated tablet contains Sacubitril Valsartan Sodium Hemipentahydrate INN equivalent to Sacubitril 49 mg & Valsartan 51 mg.

Sabicard 200 Tablet: Each film coated tablet contains Sacubitril Valsartan Sodium Hemipentahydrate INN equivalent to Sacubitril 97 mg & Valsartan 103 mg.

Description

Sacubitril/Valsartan , a new class of drug called Angiotensin Receptor Neprilysin Inhibitor (ARNI), is a US FDA-approved highly recommended treatment approach for patients with chronic heart failure. Here, Sacubitril is a neprilysin enzyme inhibitor that helps to maintain cardiovascular homeostasis and Valsartan reduces cardiac workload by reducing peripheral resistance, sodium & water retention in the body. Therefore, Sacubitril/Valsartan has transformed the treatment landscape of heart failure and widened the treatment horizon as an incredible drug of choice

Indications

Sabicard combination is indicated to:

Reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction.

Sabicard is usually administered in conjunction with other heart failure therapies, in place of an ACE inhibitor or other ARB.

Dosage & Administration

Recommended starting dose: 100 mg twice daily. Double the dose after 2 to 4 weeks to target maintenance dose of 200 mg twice daily as tolerated.

Reduced starting dose (50 mg twice daily): Patients not on ACEi/ARB or on low doses, or with severe renal or moderate hepatic impairment.

Interaction

Dual blockade of the renin-angiotensin system: Should not be used with an ACEI, aliskiren in patients with diabetes, and use with an ARB should be avoided

Potassium-sparing diuretics: Serum potassium level may be increased NSAIDs: Risk of renal impairment may be increased Lithium: Increased risk of lithium toxicity

Contraindications

Sacubitril / Valsartan is contraindicated to the following cases:

Hypersensitivity to any component

History of angioedema related to previous ACE inhibitor or ARB therapy

Concomitant use of ACE inhibitors

Concomitant use of aliskiren in patients with diabetes

Side Effects

The most common side effects are low blood pressure, high potassium, cough, dizziness, and kidney problems. It may cause some serious side-effects like

angioedema (that may cause trouble in breathing and death) and Hyperkalemia.

Pregnancy & Lactation

Pregnancy: Silodosin is not indicated for use in women.

Pediatric patients: Silodosin is not indicated for use in pediatric patients.

Renal impairment: Silodosin should be reduced to 4 mg per day in patients with moderate renal impairment. Silodosin is contraindicated in patients with severe renal impairment.

Hepatic impairment: No dosing adjustment is required in patients with mild or moderate hepatic impairment. Silodosin is contraindicated in patients with severe hepatic impairment.

Precautions & Warnings

Signs and symptoms of angioedema and hypotension should be observed

Renal function and potassium level should be monitored in susceptible patients

Storage Conditions

Store below 30 C, keep in dry place & protect from light. Keep out of reach of children.

Sabicard • 10's

৳ 405.00