Norzim Tablet: Each film-coated tablet contains Chlordiazepoxide USP 5 mg & Amitriptyline Hydrochloride USP equivalent to Amitriptyline 12.5 mg.
Chlordiazepoxide belongs to a class of drug known as benzodiazepine. It helps to reduce anxiety. It acts on the brain and nerves to produce a calming effect. Amitriptyline is a tricyclic antidepressant. It helps to improve mood and feelings of well-being, relieve depression and tension. It works by affecting the balance of serotonin in the brain. This combination (Chlordiazepoxide & Amitriptyline) is used to treat mental/mood disorders such as depression with symptoms of anxiety.
Norzim tablet is indicated for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety, insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation and anorexia.
Because of its Amitriptyline component, this combination may block the antihypertensive action of guanethidine or compounds with a similar mechanism of action.
This combination is contraindicated in patients with hypersensitivity to either benzodiazepines or tricyclic antidepressants. It should not be given concomitantly with a monoamine oxidase inhibitor. Hyperpyretic crises & severe convulsions have occurred in patients receiving a tricyclic antidepressant and a monoamine oxidase inhibitor simultaneously.
Drowsiness, dry mouth, constipation, blurred vision, dizziness and bloating.
Use in pregnancy: The safety of using bromazepam in pregnancy has not been established. Therefore, bromazepam should not be used during pregnancy.
Use in lactation: Bromazepam and its metabolites are probably excreted in human milk. Therefore, this drug should not be given to nursing mothers.
Use in children: Because of the lack of sufficient clinical experience, bromazepam is not recommended for use in patients less than 18 years of age.
Close supervision is required when Chlordiazepoxide and Amitriptyline combination is given to hyperthyroid patients or those on thyroid medication. The usual precautions should be observed when treating patients with impaired renal or hepatic function. Patients with suicidal ideation should not have easy access to large quantities of the drug. The possibility of suicide in depressed patients remains until significant remission occurs.
Store below 30 C, keep in dry place & protect from light. Keep out of reach of children.