Naburel 500 mg Tablet: Each film-coated tablet contains Nabumetone USP 500 mg.
Naburel 750 mg Tablet: Each film-coated tablet contains Nabumetone USP 750 mg.
Nabumetone (Naburel) is a prodrug that is converted into its active form after liver metabolism, offering reduced renal and gastrointestinal side effects compared to conventional NSAIDs. It acts by inhibiting cyclooxygenase (COX) enzymes and provides effective relief from pain and inflammation in patients with chronic arthritis.
Naburel is indicated for relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis, vomiting.
Central Nervous System: Dizziness, headache, fatigue, increased sweating, insomnia, nervousness, somnolence.
Dermatologic: Pruritus, rash.
Special Senses: Tinnitus.
Miscellaneous: Edema.
Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of an NSAID results in a dose-dependent decrease in prostaglandin synthesis and, secondarily, in a reduction of renal blood flow, which may precipitate overt renal decompensation. NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at a greater risk. NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Store below 30 C, keep in dry place & protect from light. Keep out of reach of children.