Diflu-50 Capsule: Each capsule contains Fluconazole USP 50 mg.
Diflu-150 Capsule: Each capsule contains Fluconazole USP 150 mg.
Diflu-200 Capsule: Each capsule contains Fluconazole USP 200 mg.
Diflu Powder for Suspension: When prepared, each 5 ml contains Fluconazole USP 50 mg.
Fluconazole is the first of a new subclass of synthetic triazole antifungal agent which acts by inhibition of the ergosterol component of the fungal cell membrane. It is active against a broad spectrum of fungal pathogens and is available for oral use.
It is indicated in the treatment of vaginal candidiasis, oropharyngeal & oesophageal candidiasis, candidal urinary tract infection, peritonitis, systemic candidiasis and cryptococcal meningitis.
Adults:
Neonates: 3–12 mg/kg every 48–72 hours depending on post-natal age.
Rifampicin reduces plasma concentration of Fluconazole. Fluconazole enhances the effect of nicoumalone, warfarin and phenytoin. It also increases the plasma concentration of sulphonylureas & theophlline.
It is contraindicated to patients hypersensitive to this drug and in advanced liver disease and in nursing mother.
Therapy with Fluconazole is well tolerated. The common adverse effects are nausea. abdominal pain, vomiting, diarrhoea, headache and skin rash.
Use in pregnancy: Fluconazole should be used in pregnancy only if the potential benefit justifies the possible risk to the fetus.
Use in lactation: Fluconazole is secreted in human milk at concentrations similar to plasma. Therefore, the use of Fluconazole in nursing mothers is not recommended.
Caution should be taken in renal impairment, pregnancy and breast-feeding and the raised liver enzymes.
Store below 30 C, keep in dry place & protect from light. Keep out of the reach of children.