Acyvir Cream: Each gram cream contains Aciclovir BP 50 mg.
Aciclovir is a synthetic purine nucleotide analogue, which acts against human herpes viruses. The enzyme thymidine kinase (TK) encoded by HSV, VZV and EBV converts Acyclovir into Acyclovir monophosphate, a nucleotide analogue, which is further converted to diphosphate and triphosphate by cellular enzymes. Acyclovir triphosphate interferes with DNA polymerase and inhibits viral DNA replication with resultant chain termination following its incorporation into the growing viral DNA chain.
Acyvir Cream is indicated for the treatment of recurrent herpes labialis (cold sores).
Acyvir cream should be applied to lesions 5 times daily for 4 days.
No interactions have been found when using Aciclovir cream with other drugs. Since it is minimally absorbed into the bloodstream, systemic drug interactions are unlikely.
Aciclovir cream is contraindicated in patients with known hypersensitivity to Aciclovir, Valacyclovir, or any component of the formulation.
Common skin-related side effects that occurred when Aciclovir cream was applied include application site reactions. Aciclovir cream has the potential for irritation and contact sensitization.
Use in pregnancy and lactation: Pregnancy Category B. There are no adequate well-controlled studies in pregnant women. Aciclovir cream should be used during pregnancy only if clearly needed. Caution should be exercised when it is administered to a nursing mother.
Pediatric use: Safety and effectiveness in pediatric patients less than 12 years of age have not been established.
Aciclovir cream should only be applied on the affected external aspects of the lips and face in patients with herpes labialis. Aciclovir cream is intended for cutaneous use only and should not be used in the eye or inside the mouth or nose.
Store below 30 C in dry place & protected from light. Keep out of the reach of children.