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Anaflex

Tablet

250 mg

GENERIC NAMENaproxen

MANUFACTURED BYACI Pharmaceuticals PLC

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Available Pack Sizes:6 Sizes

Purchase Option:Full Pack

Maximum Retail Price (MRP):

Quantity

৳ 81.00/ 50's

(Unit: ৳ 9.00 / 1 Tablet)

16263

Composition

Anaflex 250 mg Tablet: Each enteric coated tablet contains Naproxen BP 250 mg.

Anaflex 500 mg Tablet: Each enteric coated tablet contains Naproxen BP 500 mg.

Anaflex SR 500 mg Tablet: Each tablet contains Naproxen BP 500 mg.

Anaflex Suspension: Each 5 ml contains Naproxen BP 125 mg.

Anaflex Gel: Each gram gel contains Naproxen BP 100 mg (Naproxen BP 10% w/w).

Description

Anaflex is a preparation of Naproxen which is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic properties. Naproxen is a propionic acid derivative related to the acrylic acid class of drugs. It works by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever and inflammation.

Indications

Treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis

Management of acute gout and acute musculoskeletal disorders (sprains, strains, direct trauma, lumbosacral pain, cervical spondylitis, tenosynovitis, fibrositis)

Relief of acute migraine attacks, post-operative pain, and primary dysmenorrhea

Dosage & Administration

Route: Oral / Topical

Adults:

RA, OA, Ankylosing Spondylitis: 500 mg–1 g daily in 2 divided doses (12-hour intervals) or 500 mg SR once daily after meals.

Acute Gout: 750 mg initial, then 250 mg every 8 hours until attack subsides.

Analgesia: 500 mg initial, then 250 mg every 6–8 hours (max 1250 mg/day).

Dysmenorrhea: 500 mg initial, then 250 mg every 6–8 hours (up to 5 days).

Children (>5 years):

Juvenile RA: 10 mg/kg/day in two divided doses at 12-hour intervals.

Topical Gel:

Apply 2–6 times daily as needed (not recommended in children).

Interaction

Warfarin and antiplatelet agents increase gastrointestinal bleeding risk; reduces renal clearance of lithium and methotrexate increasing their toxicity; ACE inhibitors, ARBs, and beta-blockers show attenuated antihypertensive efficacy; loop and thiazide diuretics show reduced natriuretic response; cyclosporine increases nephrotoxicity.

Contraindications

Naproxen is contraindicated in patients active peptic ulceration, hypersensitivity to naproxen or naproxen sodium formulations, aspirin or other NSAIDs.

Side Effects

Common: Nausea, vomiting, abdominal pain, GI bleeding, ulceration, rash, urticaria, angioedema. Less Common: Tinnitus, hearing impairment, vertigo, peripheral edema. Rare: Eosinophilic pneumonitis, thrombocytopenia, agranulocytosis, aplastic anemia, hepatitis, nephropathy, hematuria, visual disturbances, vasculitis, aseptic meningitis, ulcerative stomatitis.

Overdose

Overdose with naproxen may be characterized by drowsiness, heartbum, indigestion, nausea and vomiting. No evidences of toxicity or late sequel have been reported 5-15 months after ingestion, for three to seven days, of doses up to 3 g/day.

Pregnancy & Lactation

Category C (1st/2nd trimesters), Category D (3rd trimester). Avoid in late pregnancy due to risk of premature closure of ductus arteriosus. Lactation: Excreted in human milk; avoid during breastfeeding.

Precautions & Warnings

Use with caution in patients with history of gastrointestinal disease, asthma, allergic disease, or impaired renal and hepatic function.

Naproxen decreases platelet aggregation and prolongs bleeding time.

Storage Conditions

Store below 30°C in a cool, dry place. Protect from light and moisture. Keep away from children.

Anaflex • 50's

৳ 81.00