Actical Tablet: Each coated tablet contains Calcium Citrate Tetrahydrate USP 1200 mg equivalent to 252 mg Calcium and Calcitriol BP 0.25 mcg.
Actical is a combination of Calcium Citrate Tetrahydrate and Calcitriol. Calcium is absorbed from the GI tract which requires vitamin D. It readily enters extracellular fluid. It is excreted mostly in the feces; 20% eliminated by the kidneys. As an active form of vitamin D 3 , Calcitriol elevates the plasma levels of Calcium by stimulating intestinal Calcium uptake, increasing reabsorption of Calcium by the kidneys and possibly increasing the release of Calcium from skeletal stores. The duration of pharmacologic activity of a single dose of exogenous Calcitriol is expected to be about 3 to 5 days.
Route: Oral (with or without food)
Adults:
1 to 4 tablets daily depending on clinical condition, or as directed by a registered physician.
Thiazide diuretics increase hypercalcemia risk; digitalis glycosides increase susceptibility to cardiac arrhythmias in hypercalcemia; reduces absorption of tetracyclines, fluoroquinolones, and bisphosphonates; enzyme inducers (phenobarbital, phenytoin) enhance vitamin D catabolism.
This combination is contraindicated in patients with known hypersensitivity to calcium citrate and calcitriol or any other components of this product. It is also contraindicated for the patients with hypercalcemia,hypercalciuria and hypophosphatemia
Common: Constipation, nausea, abdominal pain, headache, hypercalcemia, hypercalciuria, muscle weakness.
Overdose
Assess patient for nausea, vomiting, anorexia, thirst, severe constipation, paralytic ileus and bradycardia. Immediate treatment should be given if these signs of hypercalcemia occur.
Category C. Calcitriol and calcium cross the placenta; use during pregnancy only if clearly indicated under physician supervision. Lactation: Excreted in breast milk; monitor infant serum calcium if used while nursing.
Store below 25°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.