Nutrition is the most important strategy to prevent osteoporosis and other bone related diseases. Calcium, magnesium and Vitamin D are the macro nutrients for bone. Without vitamin D very little calcium is absorbed. Like calcium, magnesium increases bone strength and rigidity. Recent epidemiological studies show that some micro nutrients like copper, manganese, zinc and boron play an important role in bone health. Deficiency of the micro nutrients is noticed in patients with osteoporosis.
Route: Oral
Adults: 2 tablets per day, preferably 1 tablet in the morning and 1 tablet in the evening.
Chelates with tetracyclines, quinolones, and bisphosphonates reducing their bioavailability (administer at least 2 hours apart); thiazides increase hypercalcemia risk; zinc and copper compete for intestinal absorption; corticosteroids reduce calcium uptake.
Hypersensitivity to any of the tablet ingredients. Absolute contraindications are hypercalcaemia resulting for example from myeloma, bone metastases or other malignant bone disease, sarcoidosis; primary hyperparathyroidism and vitamin D overdosage. Severe renal failure.
Less Common: Skin rash. Rare: Mild GI disturbances (constipation, flatulence, nausea, gastric pain, diarrhea), hypercalciuria, hypocalcemia.
Overdose
The most serious consequences of acute or chronic overdose is hypercalcaemia.
Category C (Compatible). Trace minerals, calcium, and vitamin D supplementation should be under medical supervision during pregnancy; avoid excessive intake. Lactation: Compatible with breastfeeding; adhere to recommended maternal daily intake.
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.