Acical-D Tablet: Each tablet contains Colecalciferol (as Vitamin D3) 200 IU, Calcium (as Calcium Carbonate) 500 mg.
Acical-D is a combination of Calcium Carbonate and Colecalciferol (Vitamin D3). Calcium is an essential mineral required for bone formation, neuromuscular activity, and cardiac function. Colecalciferol promotes active intestinal absorption of calcium and phosphorus, regulates parathyroid hormone secretion, and facilitates mineral deposition in bone matrix. Calcium is absorbed primarily in the small intestine via active transport and passive diffusion, distributed widely with 99% stored in skeletal tissue, and excreted mainly in feces and urine. Colecalciferol is absorbed from the gastrointestinal tract, hydroxylated in the liver to 25-hydroxycholecalciferol, and further converted in the kidneys to the active metabolite 1,25-dihydroxycholecalciferol, before biliary and renal elimination.
Route: Oral
Adults: 2 tablets per day, preferably 1 tablet in the morning and 1 tablet in the evening (with or without food).
Decreases oral absorption of bisphosphonates, tetracyclines, fluoroquinolones, and iron salts (administer 2-4 hours apart); thiazide diuretics increase risk of hypercalcemia; phenytoin and carbamazepine accelerate vitamin D metabolism.
Hypersensitivity to any of the tablet ingredients. Absolute contraindications are hypercalcaemia resulting for example from myeloma, bone metastases or other malignant bone disease, sarcoidosis; primary hyperparathyroidism and Vitamin D overdosage. Severe renal failure.
Less Common: Skin rash. Rare: Mild GI disturbances (constipation, flatulence, nausea, gastric pain, diarrhea), hypercalciuria, hypocalcemia.
Overdose
The most serious consequences of acute or chronic overdose is hypercalcaemia. Pharmaceutical precautions: Should be stored in cool place (below 30ºc) and dry place. Keep out of reach of children.
Category C (Compatible). Requirements for Calcium and Vitamin D increase during pregnancy; use under medical supervision without exceeding recommended daily allowances. Lactation: Compatible with breastfeeding; consider total maternal intake from all sources.
Store below 30°C in a cool, dry place. Protect from light and moisture. Keep out of reach of children.