Abaclor 250mg Capsule: Each capsule contains Cefaclor monohydrate USP 250mg.
Abaclor 500mg Capsule: Each capsule contains Cefaclor monohydrate USP 500mg.
Abaclor Powder for Suspension: Bottle containing powder for preparation of 100ml suspension, after reconstitution each 5 ml contains Cefaclor monohydrate USP 125 mg.
Abaclor Pediatric Drops: Bottle containing powder for preparation of 15ml drops, after reconstitution each 1.25 ml contains Cefaclor monohydrate USP 125 mg.
Abaclor ® is the preparation of Cefaclor, which is a semisynthetic second generation Cephalosporin antibiotic for oral administration. It is a bactericidal antibiotic act by inhibiting the cell wall synthesis of microorganisms & has greater stability against lactamase enzymes.
Route: Oral
Adults:
The usual dose is 250 mg every 8 hours. For severe infections or less susceptible organisms, doses may be doubled (maximum dosage: 4 g/day).
Note: In case of β-hemolytic Streptococcal infections, therapy should be administered for at least 10 days.
Pediatric patients (>1 month):
The usual daily dosage is 20 mg/kg/day in divided doses every 8 hours. In serious infections (such as otitis media), 40 mg/kg/day is recommended (maximum dosage: 1 g/day).
Safety and effectiveness in infants under 1 month have not been established.
Renal impairment:
Dose adjustments for moderate or severe renal impairment are not usually required.
Haemodialysis: Predialysis loading dose of 250 mg–1 g; maintenance dose of 250–500 mg every 6 hours during interdialytic period.
Preparation:
Reconstitute powder for suspension / drops with boiled and cooled water. Stable for 7 days at room temperature, 14 days in refrigerator.
Oral anticoagulants (warfarin) may increase prothrombin time/bleeding; probenecid reduces renal excretion; false-positive urinary glucose with Benedict's/Fehling's solutions.
Cefaclor is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.
Common: Diarrhea, nausea, vomiting, fever, abdominal pain. Less Common: Superinfection, elevated LDH. Rare: Transient hepatitis, cholestatic jaundice, renal dysfunction, toxic nephropathy, hemorrhage, pancytopenia.
Overdose
The toxic symptoms following an overdose of Cefaclor may include nausea, vomiting, epigastric distress, and diarrhea.
Category B. There are no adequate and well-controlled studies in pregnant women; use during pregnancy only if clearly needed. Lactation: Cefaclor is excreted in breast milk in small amounts; caution should be exercised when administered to a nursing woman.
Store below 30°C in a cool, dry place. Protect from light and moisture. Reconstituted suspension is stable for 7 days at room temperature or 14 days in a refrigerator.